Protein Assembly Mechanisms
ProteinAssembly QuaternaryStructure MacromolecularComplexes SelfOrganization
Christian Anfinsen demonstrated protein self-assembly through ribonuclease refolding experiments. Structural biologists determine quaternary structures of multi-subunit complexes. Biochemists study assembly pathways from monomers to functional complexes. Cryo-EM enables visualizing assembly intermediates revealing stepwise construction.