The World's Most Dangerous Blood Type

Real Science
Nov 23, 2019
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18 Notes in this Video

Blood Transfusion Demand: 5 Million Americans Require Transfusions Annually

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00:20

Nearly 5 million Americans need blood transfusions each year with approximately 32,000 pints of blood used daily across United States healthcare system.

ABO Blood System: Antigen-Based Classification Into Four Major Types

BloodTypes ABOSystem Antigens Immunology
02:30

ABO system classifies blood into four major types based on presence or absence of antigen A and antigen B creating A, B, AB, and O blood groups.

Antigen-Antibody Mechanism: Immune System Producing Antibodies Against Missing Antigens

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03:40

Immune system produces antibodies against any blood antigens individuals don’t possess in their own blood creating specific immune response patterns determining transfusion compatibility.

Blood Fractionation Process: Separating Red Cells From Antibody-Containing Plasma

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04:10

Blood fractionation process separates red blood cells from plasma where antibodies are located ensuring only red cells get donated without corresponding antibodies that would cause adverse recipient reactions.

Incompatibility Reaction: Antibody Agglutination Causing Fatal Blood Cell Clumping

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04:30

Type A blood recipient receiving incompatible type B blood experiences ABO incompatibility reaction where anti-B antibodies agglutinate with B antigens causing potentially fatal complications.

Universal Donor-Recipient: O Negative Donors and AB Positive Recipients

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05:10

Type AB blood individuals serve as universal recipients accepting any blood type while type O individuals serve as universal donors providing blood to any recipient type.

Rh Blood System: 61 Antigens With RhD Determining Positive-Negative Status

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05:50

Rh blood system represents second most significant blood classification containing 61 different antigens with RhD antigen being most important clinically determining positive or negative designation.

Rare Antigen Example: Vel-Negative Individuals Facing Kidney Failure Risk

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07:20

More than 99.9 percent of people carry Vel antigen but one in every 5,000 individuals lacks it facing serious transfusion complications if receiving Vel-positive blood from common donors.

Rh Null Blood Type: Only 43 Known Individuals Lacking All 61 Rh Antigens

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08:50

Rh null represents world’s rarest blood type with only 43 people discovered globally having it characterized by complete absence of all 61 antigens in Rh blood system.

Golden Blood Capability: Rh Null Accepted Where Typical Blood Types Cannot

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09:20

Rh null blood called golden blood because it can be donated to anyone with rare Rh blood type missing few antigens where other more typical blood types would cause immune reactions.

Rh Null Scarcity Danger: Only 42 Potential Donors For Life-Threatening Injuries

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09:50

Rh null blood carriers face inherently dangerous lives unable to receive blood from anyone except 42 other known Rh null individuals making injuries potentially fatal that would be treatable for others.

Blood Shipping Logistics: 4-Week Shelf Life and 4°C Temperature Requirements

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10:30

Shipping rare blood across international borders faces stupidly complicated logistics including bureaucracy, customs delays, strict temperature maintenance, and limited shelf life creating myriad issues for recipients needing timely transfusions.

Lifestyle Restrictions: Swiss Rh Null Man Avoiding Sports and Remote Travel

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11:10

One Swiss man with Rh null blood faced severe childhood and adult lifestyle restrictions including no summer camp, no outdoor sports, no travel to countries lacking modern hospitals due to transfusion unavailability fears.

Autologous Donation Strategy: Rh Null Individuals Donating Blood to Themselves

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11:40

Swiss Rh null man navigates transfusion danger by continuously donating blood to himself meaning twice yearly he donates blood kept on reserve in case he ever needs emergency transfusion.

Hemolytic Anemia Impact: Rh Null Red Cells Breaking Down Faster Than Normal

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12:20

Rh null blood carriers experience adverse health effects because Rh antigens most people possess play crucial role maintaining red blood cell membrane integrity affecting cell shape and longevity.

Donor Burden Ethical: Lifelong On-Call Status and Unreimbursed Costs

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12:50

Rh null blood donors face unfortunate burden of being on call for entire lives should need for their blood arise creating interesting ethical questions about moral obligations to help strangers at personal cost.

Newborn Emergency Case: Swiss Donor Taking Taxi to Geneva Saving Baby

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13:10

Swiss Rh null donor once received urgent call that newborn baby was in dire need of his blood type requiring him to make his way to Geneva donation center to save the baby’s life.

WWII Blood Transfusion: 200,000 Pints Flown From US to European Forces

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14:30

American Red Cross flew almost 200,000 pints of whole blood from United States to Allied forces in Europe during World War II with D-Day invasion alone requiring more than 50,000 pints for wounded soldiers.